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The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
Meta-analyses suggest that the combination of psychotherapy and antidepressant medications is more effective in treating mild and moderate forms of depression than either type of treatment alone. [27] Patients with severe symptoms may require outpatient treatment or hospitalization. [7] The treatment of a major depressive episode can be split ...
The World Health Organisation has stated that depression is a leading cause of disability worldwide and a major contributor to the global burden of disease. [5] Stephen Ilardi has described depression as a "disease of civilisation", stating "We were never designed for the sedentary, indoor, sleep-deprived, socially-isolated, fast-food-laden, frenetic pace of modern life".
The history of the medications used in mental disorders has developed a lot through years. The discovery of modern drugs prevailed during the 20th century. Lithium, a mood stabilizer, was discovered as a treatment of mania, by John F. Cade in 1949, "and Hammond (1871) used lithium bromide for 'acute mania with depression'". [14]
Catatonic depression is underdiagnosed and may impact up to 38% of acute psychiatric patients, as it creates particular symptoms as indicated above and necessitates a specific treatment approach with an emphasis on medications to relieve symptoms. [1] Catatonia affects over 10% of all persons hospitalized to psychiatric facilities.
[22] [23] Liothyronine (synthetic T 3) is a type of thyroid hormone and has been associated with improvement in mood and depression symptoms. Benzodiazepines may improve treatment-resistant depression by decreasing the adverse side effects caused by some antidepressants and therefore increasing patient compliance. [24]
Psychotic major depression (PMD), or simply psychotic depression, is the term for a major depressive episode, in particular of melancholic nature, wherein the patient experiences psychotic symptoms such as delusions or, less commonly, hallucinations. These are most commonly mood-congruent (content coincident with depressive themes). [16]
Diurnal mood variation or morning depression is a prominent [1] depression symptom characterized by gradual mood improvement through the day, reaching its peak sometime after twilight. While the main form of diurnal mood variation presents itself as described, a reversed form, with a worsening of mood towards the evening, also exists. [ 2 ]
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