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Levothyroxine is the chemical name of the manufactured version of T 4, which is metabolised more slowly than T 3 and hence usually only needs once-daily administration. Natural desiccated thyroid hormones are derived from pig thyroid glands, and are a "natural" hypothyroid treatment containing 20% T 3 and traces of T 2 , T 1 and calcitonin .
At the cellular level, T 3 is the body's more active and potent thyroid hormone. [2] T 3 helps deliver oxygen and energy to all of the body's cells, its effects on target tissues being roughly four times more potent than those of T 4. [2] Of the thyroid hormone that is produced, just about 20% is T 3, whereas 80% is produced as T 4.
As its name suggests, it depends upon the hypothalamus, the pituitary gland, and the thyroid gland. The hypothalamus senses low circulating levels of thyroid hormone (Triiodothyronine (T3) and Thyroxine (T4)) and responds by releasing thyrotropin-releasing hormone (TRH). The TRH stimulates the anterior pituitary to produce thyroid-stimulating ...
Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T 4), and then triiodothyronine (T 3) which stimulates the metabolism of almost every tissue in the body. [1]
T4 and T3 contain four and three atoms of iodine per molecule, respectively; iodine accounts for 65% of the molecular weight of T4 and 59% of T3. The thyroid gland actively absorbs iodine from the blood to produce and release these hormones into the blood, actions which are regulated by a second hormone, called thyroid-stimulating hormone (TSH ...
Liothyronine may be used when there is an impaired conversion of T 4 to T 3 in peripheral tissues. [2] The dose of liothyronine for hypothyroidism is a lower amount than levothyroxine due it being a higher concentrated synthetic medication. [2]
The hypothalamus, pancreas, and thymus also function as endocrine glands, among other functions. (The hypothalamus and pituitary glands are organs of the neuroendocrine system . One of the most important functions of the hypothalamus—it is located in the brain adjacent to the pituitary gland—is to link the endocrine system to the nervous ...
22095 Ensembl ENSG00000165409 ENSMUSG00000020963 UniProt P16473 P47750 RefSeq (mRNA) NM_000369 NM_001018036 NM_001142626 NM_001113404 NM_011648 RefSeq (protein) NP_000360 NP_001018046 NP_001136098 NP_001106875 NP_035778 Location (UCSC) Chr 14: 80.95 – 81.15 Mb Chr 12: 91.35 – 91.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The thyrotropin receptor (or TSH receptor) is a ...