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Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. " Ecthyma " means a pus forming infection of the skin with an ulcer, "gangrenosum" refers to the accompanying gangrene or necrosis.
It can be caused by infection, massage, electrical treatment, acne medication, allergies, exercise, solar radiation (), photosensitization, [3] acute radiation syndrome, mercury toxicity, blister agents, [4] niacin administration, [5] or waxing and tweezing of the hairs—any of which can cause the affected capillaries to dilate, resulting in redness.
Fifth disease, also known as erythema infectiosum and slapped cheek syndrome, [3] is a common and contagious disease caused by infection with parvovirus B19. [4] This virus was discovered in 1975 and can cause other diseases besides fifth disease. [5] Fifth disease typically presents as a rash and is most common in children.
Without treatment, some individuals may survive through late childhood or early adolescence. People with milder forms of the disorder usually live into adulthood, although they may have reduced life expectancy. Heart disease and airway obstruction are major causes of death in people with Maroteaux–Lamy syndrome. [2]
While orf is usually a benign self-limiting illness which resolves in 3-6 weeks, in the immunocompromised it can be very progressive and even life-threatening. One percent topical cidofovir has been successfully used in a few patients with progressive disease. Serious damage may be inflicted on the eye if it is infected by orf, even among ...
This often leads to long delays (e.g. 13–18 months) between the onset of initial symptoms and diagnosis. [ 9 ] [ 3 ] In addition to the signs and symptoms indicated by the POEMS acronym, the PEST acronym is used to describe some of the other signs and symptoms of the disease.
HIES often appears early in life with recurrent staphylococcal and candidal infections, pneumonias, and eczematoid skin. [20] Autosomal dominant Hyper-IgE Syndrome caused by STAT3 defects, called Job Syndrome, have characteristic facial, dental, and skeletal abnormalities.
A British study from 2008 found a median estimated life expectancy of 8.7 years for patients with Hurler syndrome. In comparison, the median life expectancy for all forms of MPS type I was 11.6 years. Patients who received successful bone marrow transplants had a 2-year survival rate of 68% and a 10-year survival rate of 64%. Patients who did ...