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Fibrocystic breast changes is a condition of the breasts where there may be pain, breast cysts, and breast masses. [1] The breasts may be described as "lumpy" or "doughy". [ 3 ] Symptoms may worsen during certain parts of the menstrual cycle due to hormonal stimulation. [ 1 ]
Causes include fibrocystic change, fibroadenomas, breast infection, galactoceles, and breast cancer. [1] Breast cancer makes up about 10% of breast masses. [1] Diagnosis is typically by examination, medical imaging, and tissue biopsy. [2] Tissue biopsy is often by fine needle aspiration biopsy. [3] Repeated examination may be required. [2]
The prognosis of phyllodes tumor is good with an overall 87% 10-year survival rate. [5] After wide-margin surgical excision, 98.7% of benign phyllodes tumors and 80% of borderline were cured. [25] In rare cases where the tumor has metastasized, the prognosis is poor. [5] This most commonly occurs in cases of malignant grade phyllodes tumor. [5]
Diagnosis involves examination, with medical imaging if only a specific part of the breast hurts. [1] In more than 75% of people the pain resolves without any specific treatment. [1] Otherwise treatments may include paracetamol or NSAIDs. [1] A well fitting bra may also help. [3] In those with severe pain tamoxifen or danazol may be used. [1]
Since both fibroadenomas and breast lumps as a sign of breast cancer can appear similar, it is recommended to perform ultrasound analyses and possibly tissue sampling with subsequent histopathologic analysis in order to make a proper diagnosis. Unlike typical lumps from breast cancer, fibroadenomas are easy to move, with clearly defined edges.
Osteitis fibrosa cystica (/ ˌ ɒ s t i ˈ aɪ t ɪ s f aɪ ˈ b r oʊ s ə ˈ s ɪ s t ɪ k ə / OSS-tee-EYE-tis fy-BROH-sə SIS-tik-ə) is a skeletal disorder resulting in a loss of bone mass, a weakening of the bones as their calcified supporting structures are replaced with fibrous tissue (peritrabecular fibrosis), and the formation of cyst-like brown tumors in and around the bone.
Applegate’s symptoms began in 2021 while she was filming the final season of Netflix’s “Dead to Me.” She revealed her diagnosis on X , formerly Twitter, later that year.
Prognosis in benign SFTs is excellent. About 8% will recur after first resection, with the recurrence usually cured after additional surgery. [3] The prognosis in malignant SFTs is much more guarded. Approximately 63% of patients will have a recurrence of their tumor, of which more than half will succumb to disease progression within two years. [3]
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