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In animal studies, the median lethal dose (LD 50) of modafinil varies among species and depends on the route of administration. In mice and rats, the LD 50 is approximately 1250 mg/kg if administered via an injection, but the oral LD 50 for rats is 3400 mg/kg. [130] [131] The LD 50 value for humans have not been established.
Armodafinil is available in the form of 50, 150, 200, and 250 mg oral tablets. [ 1 ] A 50 mg dose of armodafinil is essentially equivalent to at 100 mg dose of modafinil in terms of drug levels.
The first six characters of the GPI define the therapeutic class code, the next two pairs the drug name, and the last four define route, dosage or strength. For example GPI 58-20-00-60-10-01-05 is for the drug nortriptyline HCl cap 10 mg (an antidepressant) and can be further classified as follows: [1]
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Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil, and adrafinil, among others. [9] They are medically indicated for the treatment of certain sleep disorders , including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).
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Modafinil is a drug that helps keep people awake and alert (wakefulness-promoting agent or "eugeroic"). [ 1 ] [ 2 ] Most of the listed modafinil analogues are drugs that specifically target dopamine reuptake (reabsorption of a neurotransmitter by a neurotransmitter transporter ) with stronger effects ( selective DRIs with improved potency ...
The drug or other substance has a currently accepted medical use in treatment in the United States. Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III. The complete list of Schedule IV substances is as follows.
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