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Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys.Because necrosis is often not present, the term acute tubular injury (ATI) is preferred by pathologists over the older name acute tubular necrosis (ATN). [1]
Acute kidney injuries can be present on top of chronic kidney disease, a condition called acute-on-chronic kidney failure (AoCRF). The acute part of AoCRF may be reversible, and the goal of treatment, as with AKI, is to return the person to baseline kidney function, typically measured by serum creatinine .
Acute kidney injury was one of the most expensive conditions seen in U.S. hospitals in 2011, with an aggregated cost of nearly $4.7 billion for approximately 498,000 hospital stays. [48] This was a 346% increase in hospitalizations from 1997, when there were 98,000 acute kidney injury stays. [ 49 ]
Abdominal trauma can be life-threatening because abdominal organs, especially those in the retroperitoneal space, can bleed profusely, and the space can hold a great deal of blood. [11] Solid abdominal organs, such as the liver and kidneys , bleed profusely when cut or torn, as do major blood vessels such as the aorta and vena cava . [ 11 ]
High potassium levels may lead to potentially fatal disruptions in heart rhythm. Phosphate binds to calcium from the circulation, leading to low calcium levels in the blood. [11] Rhabdomyolysis may cause kidney failure by several mechanisms. The most important is the accumulation of myoglobin in the kidney tubules.
The chemotherapy drug 5-FU can be toxic to some people with cancer. A quick, cheap test can show if chemo is safe for a patient, but few doctors order it.
The trauma that induced the bruise may also have caused other severe and potentially fatal harm to internal organs. For example, impacts to the head can cause traumatic brain injury : bleeding, bruising and massive swelling of the brain with the potential to cause concussion , coma and death.
Abdominal CT showing left renal artery injury. Blunt abdominal trauma (BAT) represents 75% of all blunt trauma and is the most common example of this injury. [3] Seventy-five percent of BAT occurs in motor vehicle crashes, [4] in which rapid deceleration may propel the driver into the steering wheel, dashboard, or seatbelt, [5] causing contusions in less serious cases, or rupture of internal ...