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Estriol (E3), sold under the brand name Ovestin among others, is an estrogen medication and naturally occurring steroid hormone which is used in menopausal hormone therapy. [12] [4] [6] [13] It is also used in veterinary medicine as Incurin to treat urinary incontinence due to estrogen deficiency in dogs.
Vaginal smear test grades were 1 = atrophic, 2 = intermediate cells, 3 = early cornification, 4 = full cornification. Distribution of estrogen radioactivity (dpm/mg tissue or dpm/5 μL blood) in blood and tissues after a subcutaneous injection of 0.10 μg [ 3 H]6,7-estradiol or 0.11 μg [ 3 H]6,7-estrone in aqueous solution in rats.
Conjugated estrogens (Premarin) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg; Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg ...
Estriol succinate, also known as estriol disuccinate or as estriol 16α,17β-di(hydrogen succinate), is a synthetic estrane steroid and a derivative of estriol. [ 7 ] [ 29 ] [ 30 ] It is specifically the C16α and C17β disuccinate ester of estriol.
[186] [10] Vaginal estradiol can be used both as a systemic form of estradiol therapy, and at very low doses to selectively achieve a local vaginal effect without systemic effects, for instance in the treatment of menopausal symptoms such as vaginal atrophy and dryness. [10] [254] Vaginal estradiol is rapidly and almost completely absorbed. [72]
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
A vaginal tablet formulation containing 0.125 mg estradiol benzoate and 10 mg monalazone sodium (a vaginal disinfectant and spermicidal contraceptive) has been marketed under the brand name Malun 25. [43] Estradiol benzoate was also formerly available as 50 and 100 mg pellets for subcutaneous implantation and as a 2 mg/g ointment. [44
Estradiol cypionate is usually used at a dosage of 1 to 5 mg by intramuscular injection every 3 to 4 weeks in the treatment of menopausal symptoms such as hot flashes and vaginal atrophy, at a dosage of 1.5 to 2 mg by intramuscular injection once a month in the treatment of female hypoestrogenism due to hypogonadism, and at a dosage of 2 to 10 ...
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