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Polymorphous light eruption (PLE) presents with itchy red small bumps on sun-exposed skin, particularly face, neck, forearms and legs. [1] It generally appears 30 minutes to a few hours after sun exposure and may last between one and 14 days. [3] The bumps may become small blisters or plaques and may appear bloody, [3] often healing with ...
Afamelanotide, sold under the brand name Scenesse, is a medication used to prevent phototoxicity and to reduce pain from light exposure for people with erythropoietic protoporphyria. [ 1 ] [ 2 ] [ 4 ] It is a melanocortin 1 receptor (MC 1 receptor) agonist [ 1 ] and a synthetic peptide and analogue of α-melanocyte stimulating hormone . [ 1 ]
Afamelanotide (brand name Scenesse) has been approved for the treatment of erythropoietic protoporphyria in Europe and is also being investigated as a method of photoprotection in the treatment of polymorphous light eruption, actinic keratosis and squamous cell carcinoma (a form of skin cancer). [8]
An example of primary photodermatoses is Polymorphous light eruption. Polymorphous light eruption is the most common type of photodermatoses. It is most likely due to an abnormal immune system reaction to the sun. Polymorphous light eruption occurs in approximately 10 to 20 percent [3] of otherwise healthy individuals, so it is a relatively common
Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy is a skin condition that occurs most often in women receiving cobalt radiotherapy for internal cancer. [ 3 ] : 39–40
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[14] [15] [16] Afamelanotide is also being investigated as a method of photoprotection from in the treatment of polymorphous light eruption, actinic keratosis and squamous cell carcinoma (a form of skin cancer).
Losing the dark. Light pollution, the term for the brightening of the night sky by unnatural lights, is increasing worldwide. On average, skies are getting 10% brighter each year globally, with ...