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A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn 2+) which stabilizes the fold. The term zinc finger was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA.
A little larger is the BCG tuberculosis vaccine, which is 0.05ml for babies and children under 12, and 0.1ml for others. This tiny dose is inserted a couple of millimetres under the skin, producing a small blanched blister. [8] Many vaccines for intramuscular injection have 0.5ml liquid, though a few have 1ml. [a]
An Fpg-type zinc finger is also found at the C terminus of isoleucyl tRNA synthetase . [6] [7] This enzyme catalyses the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing ...
A 2006 study, investigating children exposed to the vaccine preservative thiomersal, found that levels of MT and antibodies to MT in autistic children did not differ significantly from non-autistic children. [29] A low zinc to copper ratio has been seen as a biomarker for autism and suggested as an indication that the metallothionein system has ...
In molecular biology, GATA zinc fingers are zinc-containing domains found in a number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins). Some members of this class of zinc fingers specifically bind the DNA sequence (A/T)GATA(A/G) in the regulatory regions of genes ., [ 1 ] giving rise ...
The Ikaros Zinc Finger (IkZF) family of transcription factors are known regulators of hematopoietic cell development and many immune cells including that of CD4 + T cells. The IkZF family consists of five members: Ikaros (encoded by the gene Ikzf1 ), Helios ( Ikzf2 ), Aiolos ( Ikzf3 ), Eos ( Ikzf4 ), and Pegasus ( Ikzf5 ).
Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. [5] [6] [7]ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.
Zinc fingers help read DNA sequences. Zinc is an essential trace element for humans [1] [2] [3] and other animals, [4] for plants [5] and for microorganisms. [6] Zinc is required for the function of over 300 enzymes and 1000 transcription factors, [3] and is stored and transferred in metallothioneins.