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An oncovirus or oncogenic virus is a virus that can cause cancer. [4] This term originated from studies of acutely transforming retroviruses in the 1950–60s, [ 5 ] when the term oncornaviruses was used to denote their RNA virus origin. [ 6 ]
A major obstacle to the success of oncolytic viruses is the patient immune system which naturally attempts to deactivate any virus. This can be a particular problem for intravenous injection, where the virus must first survive interactions with the blood complement and neutralising antibodies. [42]
Herpesviruses also cause cancer in animals, especially leukemias and lymphomas. [13] Human T cell lymphotropic virus was the first human retrovirus discovered by Robert Gallo and colleagues at NIH. [20] The virus causes Adult T-cell leukemia, a disease first described by Takatsuki and colleagues in Japan [21] and other neurological diseases ...
The term can also be understood as DNA transfection using a viral vector. Figure 1: Hepatitis-B virions. Viral transformation can occur both naturally and medically. Natural transformations can include viral cancers, such as human papillomavirus (HPV) and T-cell Leukemia virus type I.
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
A number of viruses named oncoviruses cause cancer. These are mainly human papilloma virus causing cervical carcinoma, and Epstein-Barr virus causing B cell lymphomas and nasopharyngeal carcinomas. Kaposi sarcoma virus and Merkel cell polyoma virus cause skin cancers. Human T-lymphotropic virus (HTLV) causes T cell leukemias.
Despite the promises of early in vivo lab work, these viruses do not specifically infect cancer cells, but they still kill cancer cells preferentially. [3] While overall survival rates are not known, short-term response rates are approximately doubled for H101 plus chemotherapy when compared to chemotherapy alone. [ 3 ]
It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer. [3] Approximately 80% of Merkel cell carcinoma (MCC) tumors have been found to be infected with MCV. MCV appears to be a common—if not universal—infection of older children and adults.