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The entorhinal cortex is the first area of the brain to be affected in Alzheimer's disease; in year 2013, a functional magnetic resonance imaging study has localised the area to the lateral entorhinal cortex. [15]
Sarcopenia is linked to an increased risk of dementia, a new study finds, ... and the size of certain brain regions important for memory, like the hippocampus and entorhinal cortex.
“The entorhinal cortex is a brain area immediately adjacent to the hippocampus and has been recognized for decades as the area where Alzheimer’s disease pathology accumulates very early in the ...
Alzheimer's disease involves damage to the entorhinal cortex. This area contains most of the cells involved in cognitive mapping and this could suggest why patients suffering from Alzheimer's disease tend to forget or become lost.
Rat studies indicate that lesioning of the subiculum decreases the spread of amyloid-beta in rat models of Alzheimer's disease. Alzheimer's disease pathology is thought to have prion-like properties. The disease tends to spread in characteristic sequence from the entorhinal cortex through the subiculum. [12]
However, later work did confirm that the olfactory bulb does project into the ventral part of the lateral entorhinal cortex, and field CA1 in the ventral hippocampus sends axons to the main olfactory bulb, [42] the anterior olfactory nucleus, and to the primary olfactory cortex. There continues to be some interest in hippocampal olfactory ...
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