Search results
Results from the WOW.Com Content Network
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine . It is of interest as a precursor to the monoaminergic neurotoxin MPP + , which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain .
A close analogue of 2′-CH 3-MPTP is 2′-NH 2-MPTP, which, in contrast to 2′-CH 3-MPTP and MPTP, is a serotonergic and noradrenergic neurotoxin with no effect on dopaminergic neurons. [10] Numerous other neurotoxic MPTP analogues have also been synthesized. [8] 2′-CH 3-MPTP was first described in the scientific literature by 1986. [4]
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes permanent symptoms of Parkinson's disease. (–)-Mitragynine is a naturally occurring tetrahydropyridine. 2,3,4,5-Tetrahydropyridine, a colorless liquid, is commercially available. It is an imine. Illustrating another isomer of tetrahydropyridine, 6-acetyl-2,3,4,5-tetrahydropyridine occurs ...
2′-NH 2-MPTP, also known as 2′-amino-MPTP, is a monoaminergic neurotoxin that was derived from MPTP and is used in scientific research to lesion brain monoaminergic systems in animals. [ 1 ] [ 2 ] Whereas MPTP is a selective dopaminergic neurotoxin , 2′-NH 2 -MPTP is a specific serotonergic and noradrenergic neurotoxin that does not ...
The researchers discovered that the opiates were tainted with MPTP, which is the biological precursor to the neurotoxic MPP +. [2] The MPTP was present in the illicitly synthesized meperidine analog as an impurity, which had a precedent in a 1976 case involving a chemistry graduate student synthesizing meperidine and injecting the resulting ...
The P. D. Hinduja National Hospital and Medical Research Centre is a multi-specialty, tertiary-care hospital in Mumbai, India. It was founded in 1951 by Parmanand Deepchand Hinduja, in collaboration with the Massachusetts General Hospital, the main teaching hospital of Harvard Medical School, Boston. [2]
From January 2008 to December 2012, if you bought shares in companies when William H. Gray, III joined the board, and sold them when he left, you would have a -17.6 percent return on your investment, compared to a -2.8 percent return from the S&P 500.
[17] 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mediated activation of caspase-9 via cytochrome-c release has been shown to result in the activation of caspase-8 and Bid cleavage. [18] Aspirin and Curcumin (diferuloylmethane) too activate caspase-8 to cleave and translocate Bid, induced a conformational change in and translocation of ...