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In medicine, a contraindication is a condition (a situation or factor) that serves as a reason not to take a certain medical treatment due to the harm that it would cause the patient. [ 1 ] [ 2 ] Contraindication is the opposite of indication , which is a reason to use a certain treatment.
Clinical NSAID ulcers are related to the systemic effects of NSAID administration. Such damage occurs irrespective of the route of administration of the NSAID (e.g., oral, rectal, or parenteral) and can occur even in people who have achlorhydria. [76] Ulceration risk increases with therapy duration, and with higher doses.
Topics of pharmacodynamics. Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).The effects can include those manifested within animals (including humans), microorganisms, or combinations of organisms (for example, infection).
Some adverse effects occur only when starting, increasing or discontinuing a treatment. Using a drug or other medical intervention which is contraindicated may increase the risk of adverse effects. Adverse effects may cause complications of a disease or procedure and negatively affect its prognosis.
Fluconazole is contraindicated in patients who: [14] Drink alcohol; have known hypersensitivity to other azole medicines such as ketoconazole; [2] are taking terfenadine, if 400 mg per day multidose of fluconazole is administered; [2] concomitant administration of fluconazole and quinidine, especially when fluconazole is administered in high ...
Another systematic review completed in the same year suggested that there is limited evidence if the combined used of Metformin with Sulphonylurea compared to the combination of Metformin plus another glucose-lowering intervention, provides benefit or harm in mortality, severe adverse events, macrovascular and microvascular complications. [14]
Contraindications for the use of ephedrine include: closed-angle glaucoma, phaeochromocytoma, asymmetric septal hypertrophy (idiopathic hypertrophic subaortic stenosis), concomitant or recent (previous 14 days) monoamine oxidase inhibitor (MAOI) therapy, general anaesthesia with halogenated hydrocarbons (particularly halothane ...
Use during pregnancy is contraindicated due to the risk of birth defects. [8] [1] It is in the retinoid family of medications. [9] Tretinoin was patented in 1957 and approved for medical use in 1962. [13] It is on the World Health Organization's List of Essential Medicines. [14] Tretinoin is available as a generic medication. [15]