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Risk of toxicity due to vitamin B 12 is low. [2] Vitamin B 12 deficiency in the US and the UK is estimated to occur in about 6 percent of those under the age of 60, and 20 percent of those over the age of 60. [4] In Latin America, about 40 percent are estimated to be affected, and this may be as high as 80 percent in parts of Africa and Asia. [1]
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Pernicious anaemia is a lifelong condition that affects nearly 5 in 100,000 people in the UK.
Once you get an evaluation, a doctor will usually order a blood test to check for a vitamin B12 deficiency, along with other potential factors that could cause dementia-like symptoms, Sachdev says.
Vitamin B 12 deficiency is a widespread condition that is particularly prevalent in populations with low or no consumption of animal foods. [9] Such diets can be due to a variety of reasons, such as low socioeconomic status or personal choice (i.e., veganism, vegetarianism).
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
The disease can also be caused by inhalation of nitrous oxide, which inactivates vitamin B12. [11] Vitamin E deficiency, which is associated with malabsorption disorders such as cystic fibrosis and Bassen-Kornzweig syndrome, [12] can cause a similar presentation due to the degeneration of the dorsal columns. [5]
The complications of diabetes can dramatically impair quality of life and cause long-lasting disability. Overall, complications are far less common and less severe in people with well-controlled blood sugar levels. [3] [4] [5] Some non-modifiable risk factors such as age at diabetes onset, type of diabetes, gender, and genetics may influence risk.
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