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The sonic hedgehog (SHH) signaling molecule assumes various roles in patterning the central nervous system (CNS) during vertebrate development. One of the most characterized functions of SHH is its role in the induction of the floor plate and diverse ventral cell types within the neural tube. [41]
The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include cancer ...
As Hoxb-8 spreads to more anterior regions, Shh is induced in the area that will become the ZPA. Shh is only induced in the anterior region because of signals from the AER. Experiments done by Heikinheimo et al. show that when the AER is removed, beads that express FGF are sufficient to induce Shh signaling in the ZPA. [12]
Sonic Hedgehog (Shh) is the most potent of the three Hedgehog ligands. Inhibition of Shh expression and activity can thus be an effective way of restricting Hedgehog signaling-mediated tumor progression. RU-SKI 43 inhibits the activity of SHHat, an enzyme that catalyzes the palmitoylation of Shh. [56]
Sonic hedgehog (shh) signaling from the ZLI is crucial in the development of the diencephalon, [1] which develops into the thalamus, the pretectum, and the anterior tegmental structures. [2] The ZLI together with the prethalamus and thalamus make up the mid-diencephalic territory (MDT). [3]
The notochord secretes a protein called sonic hedgehog (SHH), a key morphogen regulating organogenesis and having a critical role in signaling the development of motor neurons. [21] The secretion of SHH by the notochord establishes the ventral pole of the dorsal-ventral axis in the developing embryo.
In the central nervous system (CNS), overall cell fate mapping is typically directed by the sonic hedgehog (Shh) morphogen signaling pathway. In the spinal cord, Shh is directed by both the notochord and floor plate regions which ultimately drives the organization of neural and glial progenitor populations.
They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog gene expression. It is also thought to play a role during embryogenesis. [6]