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Human brain in the coronal orientation. Amygdalae are shown in dark red. The amygdala (/ ə ˈ m ɪ ɡ d ə l ə /; pl.: amygdalae / ə ˈ m ɪ ɡ d ə l i,-l aɪ / or amygdalas; also corpus amygdaloideum; Latin from Greek, ἀμυγδαλή, amygdalē, 'almond', 'tonsil' [1]) is a paired nuclear complex present in the cerebral hemispheres of vertebrates.
The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain. [1] Its various components support a variety of functions including emotion, behavior, long-term memory, and olfaction. [2]
Neuronal activity in the central nucleus of the amygdala was found to be a critical brain substrate for incubation of methamphetamine craving as well as neurobiological responses to ethanol. [3] [20] [21] [22] Neurons in the central nucleus of the amygdala were found to respond to, and control, predatory hunting. [23]
Amygdala; Brain stem. Medulla oblongata; Midbrain; Pons; Significant components: Arcuate fasciculus – neural pathway connecting the junction between the temporal and parietal lobes with the frontal cortex in the brain; Broca's area – region of the brain with functions linked to speech production
The ventromedial prefrontal cortex (vmPFC) is a part of the prefrontal cortex in the mammalian brain.The ventral medial prefrontal is located in the frontal lobe at the bottom of the cerebral hemispheres and is implicated in the processing of risk and fear, as it is critical in the regulation of amygdala activity in humans. [2]
The basolateral amygdala and nucleus accumbens shell together mediate specific Pavlovian-instrumental transfer, a phenomenon in which a classically conditioned stimulus modifies operant behavior. [6] [7] One of the main functions of the basolateral complex is to stimulate the fear response. The fear system is intended to avoid pain or injury.
The subcortical areas receiving projections are the amygdala, caudate nucleus and hippocampus. It is unknown if there are cortical regions that do not receive input from the claustrum. Additionally, large or small types of aspiny neurons are reported in the monkey brain, which are classified as “local circuit neurons".
The extended amygdala is a macrostructure in the brain that is involved in reward cognition and defined by connectivity and neurochemical staining. [1] [2] It includes the central medial amygdala, sublenticular substantia innominata, and the bed nucleus of the stria terminalis. [1] The boundaries are indistinct in Nissl stained sections. [2]