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Testosterone undecanoate has a very long elimination half-life and mean residence time when given as a depot intramuscular injection. [27] [7] [8] Its elimination half-life is 20.9 days and its mean residence time is 34.9 days in tea seed oil, while its elimination half-life is 33.9 days and its mean residence time is 36.0 days in castor oil.
The bioavailability of oral testosterone undecanoate taken with food is 3 to 7%. [32] [40] Inappropriately high levels of testosterone have been observed with 10 to 40 mg/day oral testosterone undecanoate in women. [41] [42] The oral bioavailability of testosterone undecanoate in young women after a single 40 mg dose was found to be 6.8 ± 3.3% ...
Pharmacokinetics of testosterone esters Testosterone ester Form Route T max Tooltip Time to peak levels t 1/2 Tooltip Elimination half-life MRT Tooltip Mean residence time; Testosterone undecanoate: Oil-filled capsules: Oral? 1.6 hours: 3.7 hours Testosterone propionate: Oil solution: Intramuscular injection? 0.8 days: 1.5 days Testosterone ...
In the 1970s, testosterone undecanoate was introduced for oral use in Europe, [129] although intramuscular testosterone undecanoate had already been in use in China for several years. [130] Intramuscular testosterone undecanoate was not introduced in Europe and the United States until much later (in the early to mid 2000s and 2014, respectively).
Testosterone decanoate has been investigated as a potential long-acting injectable male contraceptive. [ 4 ] [ 6 ] [ 7 ] [ 8 ] It has a longer duration of action than testosterone enanthate , but its duration is not as prolonged as that of testosterone undecanoate .
Testosterone. Even the word alone sounds manly. For men, testosterone is important for drive, fertility, heart health, bone health, energy and mood — to name just a few benefits.
Testosterone propionate is administered in oil via intramuscular injection. [1] [2] It has a relatively short elimination half-life and mean residence time of 2 days and 4 days, respectively. [1] [2] As such, it has a short duration of action and must be administered two to three times per week. [16]
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
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