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Sizing (size reduction, milling, crushing, grinding, pulverization) is an important step in the process of tablet manufacturing. In manufacturing of compressed tablets, the mixing or blending of several solid pharmaceutical ingredients is easier and more uniform if the ingredients are about the same size. This provides a greater uniformity of dose.
Trituration (Latin, grinding) is the name of several different methods used to process materials. In one sense, it is a form of comminution (reducing the particle size of a substance). In another sense, it is the production of a homogeneous powdered material by mixing and grinding component materials thoroughly. [ 1 ]
Comminution is the reduction of solid materials from one average particle size to a smaller average particle size, by crushing, grinding, cutting, vibrating, or other processes. [ 1 ] [ 2 ] In geology , it occurs naturally during faulting in the upper part of the Earth's crust . [ 3 ]
A tablet can be formulated to deliver an accurate dosage to a specific site in the body; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. The tablet is just one of the many forms that an oral drug can take such as syrups, elixirs, suspensions, and emulsions.
In the case of grinding, the solid particles are formed when the grinding units of the device rub against each other while particles of the solid are trapped in between. Methods like crushing and cutting are also used for reducing particle diameter, but produce more rough particles compared to the two previous techniques (and are therefore the ...
The primarily used equipment in crushing are jaw crushers, gyratory crushers and cone crushers whereas rod mills and ball mills, usually closed circuited with a classifier unit, are generally employed for grinding purposes in a mineral processing plant. Crushing is a dry process whereas grinding is generally performed wet and hence is more ...
In the 1930s through early 1950s, Bond developed a new theory of comminution that introduced an index, called the 'Bond Work Index', which relates power consumption in crushing and grinding to the feed and product size distribution. [1] His theory and index were introduced in a widely cited 1952 journal article. [2]
Comminution – reduces the size of physical particles (it exists between crushing and grinding) Frasch process – for extracting molten sulfur from the ground; Froth flotation, flotation process – separating minerals through flotation; Liquid–liquid extraction – dissolving one substance in another