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Serous carcinoma is a Type II endometrial tumor that makes up 5–10% of diagnosed endometrial cancer and is common in postmenopausal women with atrophied endometrium and black women. Serous endometrial carcinoma is aggressive and often invades the myometrium and metastasizes within the peritoneum (seen as omental caking ) or the lymphatic system.
Endometrial cancer: obesity, metabolic syndrome, type 2 diabetes, tamoxifen use, unopposed estrogens, late menopause, family history of the condition [1] Uterine sarcoma: radiation therapy to the pelvis [2] Treatment: Surgery, radiation therapy, chemotherapy, hormone therapy, targeted therapy [1] [2] Frequency: 3.8 million (2015) [4] Deaths ...
Unlike the more common low-grade endometrioid endometrial adenocarcinoma, uterine serous carcinoma does not develop from endometrial hyperplasia and is not hormone-sensitive. It arises in the setting of endometrial atrophy and is classified as a type II endometrial cancer. [1]
As with endometrial carcinomas, the prognosis is influenced by the grade and type of the adenocarcinoma, being poorest with serous differentiation. MMMTs are highly malignant; a stage I tumor has an expected five-year survival rate of 50%, while the overall five-year survival rate is less than 20%. [1] Staging of uterine MMMTs is as follows: [3]
Endometrioid carcinoma can also arise in the endometrium. [ 4 ] [ 5 ] Grades 1 and 2 are considered "type 1" endometrial cancer , while grade 3 is considered "type 2".
Histopathology of a pelvic lymph node in a patient with endometrial adenocarcinoma (FIGO grade 1): - Left panel shows H&E staining and low magnification, where any presence of small metastases is hard to see. - Middle panel shows immunohistochemistry for CK AE1/AE3, which highlights even small tumor nests.
Endometrial intraepithelial neoplasia (EIN) is a premalignant lesion of the uterine lining that predisposes to endometrioid endometrial adenocarcinoma. It is composed of a collection of abnormal endometrial cells, arising from the glands that line the uterus , which have a tendency over time to progress to the most common form of uterine cancer ...
Progestins (progesterone-like drugs) such as megestrol acetate and medroxyprogesterone acetate have been used for the treatment of hormone-responsive, advanced breast cancer, endometrial cancer, and prostate cancer. Progestins are also used in the treatment of endometrial hyperplasia, a precursor to endometrial adenocarcinoma. The exact ...