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  2. Reductive amination - Wikipedia

    en.wikipedia.org/wiki/Reductive_amination

    The intermediate imine can be isolated or reacted in-situ with a suitable reducing agent (e.g., sodium borohydride) to produce the amine product. [2] Intramolecular reductive amination can also occur to afford a cyclic amine product if the amine and carbonyl are on the same molecule of starting material. [4]

  3. Schmidt reaction - Wikipedia

    en.wikipedia.org/wiki/Schmidt_reaction

    Reaction mechanism for the amine formation from a carboxylic acid via Schmidt reaction. In the reaction mechanism for the Schmidt reaction of ketones , the carbonyl group is activated by protonation for nucleophilic addition by the azide, forming azidohydrin 3 , which loses water in an elimination reaction to diazoiminium 5.

  4. Carbonyl reduction - Wikipedia

    en.wikipedia.org/wiki/Carbonyl_reduction

    The first step involves deprotonation of the carboxylic acid. The final step in the reduction of carboxylic acids and esters is hydrolysis of the aluminium alcoxide. [8] Esters (and amides) are more easily reduced than the parent carboxylic acids. Their reduction affords alcohols and amines, respectively. [9]

  5. Carboxylic acid - Wikipedia

    en.wikipedia.org/wiki/Carboxylic_acid

    In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group (−C(=O)−OH) [1] attached to an R-group. The general formula of a carboxylic acid is often written as R−COOH or R−CO 2 H, sometimes as R−C(O)OH with R referring to an organyl group (e.g., alkyl, alkenyl, aryl), or hydrogen, or other groups ...

  6. 1-Ethyl-3- (3-dimethylaminopropyl)carbodiimide - Wikipedia

    en.wikipedia.org/wiki/1-Ethyl-3-(3-dimethylamino...

    The scheme above shows the general mechanistic steps for EDC-mediated coupling of carboxylic acids and amines under acidic conditions. The tetrahedral intermediate and the aminolysis steps are not shown explicitly. EDC couples primary amines, and other nucleophiles, [5] to carboxylic acids by creating an activated ester leaving group. First ...

  7. Infrared spectroscopy correlation table - Wikipedia

    en.wikipedia.org/wiki/Infrared_spectroscopy...

    carboxylic acids/derivates saturated carboxylic acids 1710 unsat./aromatic carb. acids 1680–1690 esters and lactones: 1735 influenced by conjugation and ring size (as with ketones) anhydrides 1760 1820 acyl halides: 1800 amides: 1650 associated amides carboxylates (salts) 1550–1610 amino acid zwitterions 1550–1610 O─H alcohols, phenols

  8. Aminolysis - Wikipedia

    en.wikipedia.org/wiki/Aminolysis

    Another common example is the reaction of a primary amine or secondary amine with a carboxylic acid or with a carboxylic acid derivative to form an amide. This reaction is widely used, especially in the synthesis of peptides. On the simple addition of an amine to a carboxylic acid, a salt of the organic acid and base is obtained.

  9. Amino acid - Wikipedia

    en.wikipedia.org/wiki/Amino_acid

    As both the amine and carboxylic acid groups of amino acids can react to form amide bonds, one amino acid molecule can react with another and become joined through an amide linkage. This polymerization of amino acids is what creates proteins. This condensation reaction yields the newly formed peptide bond and a molecule of water.