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Glycopyrronium bromide/formoterol, sold under the brand name Bevespi Aerosphere, is a combination medication used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). [ 2 ] [ 3 ] It is a combination of glycopyrronium bromide and formoterol .
Budesonide/glycopyrronium bromide/formoterol, sold under the brand name Breztri Aerosphere among others, is an inhalable fixed-dose combination medication for the treatment of chronic obstructive pulmonary disease (COPD). [5] [6] [7] It contains budesonide, glycopyrronium bromide, and formoterol fumarate dihydrate. [5] [6] [7] It is inhaled. [5 ...
Formoterol, also known as eformoterol, is a long-acting β 2 agonist (LABA) used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease (COPD). Formoterol has an extended duration of action (up to 12 h) compared to short-acting β 2 agonists such as salbutamol (albuterol), which are effective for 4 h to 6 h.
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The combination of beclometasone, formoterol, and glycopyrronium bromide has been shown to be effective at relieving symptoms of COPD in three main studies involving over 5,500 participants whose symptoms were not controlled well enough by either combinations of two other COPD medicines or by a muscarinic receptor antagonist alone. [3] [4]
Glycopyrronium bromide affects the gastrointestinal tracts, liver and kidney but has a very limited effect on the brain and the central nervous system.In horse studies, after a single intravenous infusion, the observed tendencies of glycopyrronium followed a tri-exponential equation, by rapid disappearance from the blood followed by a prolonged terminal phase.
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