Ad
related to: macrophage survival
Search results
Results from the WOW.Com Content Network
Macrophages (/ ˈ m æ k r oʊ f eɪ dʒ / ... APRIL and IL-6 secreted by macrophage precursors in the bone marrow help maintain survival of plasma cells homed to the ...
M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. [7] M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell ...
This promotes proliferation and survival of injured tubular epithelial cells and promotes anti-inflammatory phenotypes in resident macrophage to promote kidney healing. [10] Lastly, activation of CSF1R is a strong chemokinetic signal, inducing macrophage polarization and chemotaxis towards the source of CSF1R ligand.
This allows the bacterium to maintain survival in the human reservoir by undermining host resistance and acquired immune responses. [1] These mechanisms include the inhibition of T-cell proliferation and of macrophage microbicidal activity via diminished IFN-γ response.
Some survival strategies often involve disrupting cytokines and other methods of cell signaling to prevent the phagocyte's responding to invasion. [124] The protozoan parasites Toxoplasma gondii , Trypanosoma cruzi , and Leishmania infect macrophages, and each has a unique way of taming them. [ 124 ]
AIM is highly expressed in foam macrophages within atherosclerotic plaques, promoting macrophage survival and inflammatory responses. AIM deficiency in mice shows improved outcomes after myocardial infarction, including increased survival, reduced heart rupture, and altered macrophage profiles.
The composition of monocyte-derived macrophages and tissue-resident macrophages in the tumor microenvironment depends on the tumor type, stage, size, and location, thus it has been proposed that TAM identity and heterogeneity is the outcome of interactions between tumor-derived, tissue-specific, and developmental signals. [2]
The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one. [ citation needed ] " Reticuloendothelial system " is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophages .
Ad
related to: macrophage survival