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Of the 97 children in the hypothermia group and the 93 children in the control group, death or an IQ score below 70 occurred in 46 (47%) and 58 (62%), respectively (P=0.06); death occurred in 27 (28%) and 41 (44%) (P=0.04); and death or severe disability occurred in 38 (41%) and 53 (60%) (P=0.03). The CoolCap study gathered data using the ...
Monitoring of methemoglobin needed when nitric oxide is in use. Nitric oxide with oxygen (O 2) in combination produces another by-product chemical compound nitrogen dioxide (NO 2). The higher the oxygen concentration and nitric oxide therapy duration and lower ventilator flow rate the higher amount of NO 2 will be produced. NO 2 is toxic and its
Biological functions of nitric oxide are roles that nitric oxide plays within biology. Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of N O . In mammals including humans, nitric oxide is a signaling molecule involved in several physiological and pathological processes. [ 1 ]
Bellerophon Therapeutics, Inc. (BLPH) is a clinical development-stage medical therapeutics company focused on the development and commercialization of a novel nitric oxide therapy which, if ...
Roberta A. Ballard is recognized for her contributions to neonatal medicine. In 1965, she graduated from the University of Chicago's medical school and has dedicated much of her life to research on newborn prenatal health. [1] Specifically, Dr. Ballard studies ways to treat and prevent chronic lung disease in premature infants. Some of her ...
The current "trinity" of gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide, have ironically been discarded as useless toxic gases throughout history. These molecules are a classic example of dose-dependent hormesis such that low-dose is beneficial whereas absence or excessive dosing is toxic. The beneficial effects of these ...
Until the 1980s, nitric oxide, a product of fossil fuel combustion, was thought only to play a role the detrimental effects of air pollution on the respiratory tract. [17] In 1987, experiments with coronary arteries showed that nitric oxide was the long sought endothelium-derived relaxing factor.
Meconium aspiration syndrome (MAS), also known as neonatal aspiration of meconium, is a medical condition affecting newborn infants. It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. Therefore, MAS has a wide range of severity depending on ...
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