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Gastroesophageal reflux disease (GERD) or gastro-oesophageal reflux disease (GORD) is a chronic upper gastrointestinal disease in which stomach content persistently and regularly flows up into the esophagus, resulting in symptoms and/or complications. [6][7][10] Symptoms include dental corrosion, dysphagia, heartburn, odynophagia, regurgitation ...
It is often treated with proton pump inhibitors. If left untreated, the chronic damage to the esophageal tissues poses a risk of developing cancer. [6] A meta-analysis showed risk factors for developing GERD included age equal to or greater than 50, smoking, the use of non-steroid anti-inflammatory medications, and obesity. [16]
Heartburn, also known as pyrosis, cardialgia or acid indigestion, [2] is a burning sensation in the central chest or upper central abdomen. [3][4][5] Heartburn is usually due to regurgitation of gastric acid (gastric reflux) into the esophagus. It is the major symptom of gastroesophageal reflux disease (GERD). [6]
Gastroesophageal reflux disease (GERD) is another risk factor that is often linked with Mallory–Weiss syndrome. However, not every individual with Mallory–Weiss syndrome will have these risk factors. Individuals with Mallory–Weiss syndrome will have hematemesis (vomiting up blood), however the symptoms can vary. [2]
Despite being a cause of GERD and a risk factor for gastric cancer, the infection seems to be associated with a reduced risk of esophageal adenocarcinoma of as much as 50%. [ 31 ] [ 32 ] The biological explanation for a protective effect is somewhat unclear. [ 32 ]
While age is the most significant risk factor for Parkinson’s disease, around 4% of cases are diagnosed in people under the age of 50. ... (GERD), peptic ulcers, and prolonged use of non ...
There are no specific symptoms although symptoms of GERD may be present for years prior as it is associated with a 10–15% risk of Barrett's esophagus. [22] Risk factors include chronic GERD for more than 5 years, being age 50 or older, being non-Hispanic white, being male, having a family history of this disorder, belly fat , and a history of ...
Helicobacter pylori is a risk factor for gastric adenocarcinomas. [168] Treatment is highly aggressive with even localized disease being treated sequentially with chemotherapy and radiotherapy before surgical resection. [169] Since this cancer, once developed, is independent of H. pylori infection, eradication regimens are not used. [170]