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Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
Aspartame is an artificial non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. [4] 200 times sweeter than sucrose, it is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSweet, Equal, and Canderel. [4]
In the United States, six high-intensity sugar substitutes have been approved for use: aspartame, sucralose, neotame, acesulfame potassium (Ace-K), saccharin and advantame. [3] Food additives must be approved by the FDA, [ 3 ] and sweeteners must be proven as safe via submission by a manufacturer of a GRAS document. [ 44 ]
"With a can of diet soft drink containing 200 or 300 mg of aspartame, an adult weighing (154 pounds) would need to consume more than 9–14 cans per day to exceed the acceptable daily intake ...
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Mice on the aspartame diet had persistently high insulin levels, suggesting that long-term consumption of this artificial sweetener may lead to insulin resistance, which greatly increases the risk ...
The artificial sweetener aspartame has been the subject of several controversies since its initial approval by the U.S. Food and Drug Administration (FDA) in 1974. The FDA approval of aspartame was highly contested, beginning with suspicions of its involvement in brain cancer, [1] alleging that the quality of the initial research supporting its safety was inadequate and flawed, and that ...
By comparison, original Coke contains high-fructose corn syrup, a type of sugar, in place of the aspartame. Aspartame, a sugar substitute , is what makes Diet Coke taste sweet.