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Vitamin K2 may have a protective effect on bone mineral density and reduced risk of hip, vertebral and non-vertebral fractures. [11] These effects appear to be accentuated when combined with vitamin D and in the setting of osteoporosis. [1] Research suggests that vitamin K 2 (Menaquinone 7, MK-7]) may reduce the rate and severity of night time ...
Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2) are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
The active vitamin D metabolite, calcitriol, exerts its biological effects by binding to the vitamin D receptor (VDR), which is primarily located in the nuclei of target cells. [ 1 ] [ 13 ] When calcitriol binds to the VDR, it enables the receptor to act as a transcription factor , modulating the gene expression of transport proteins involved ...
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Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
There has been rare reports of oral vitamin K adverse effects. Intravenous vitamin K admission had reports of low blood pressure, shortness of breath, flushing, and other serious allergic reactions. [6] [13] Vitamin K needs to be diluted to an aqueous solution for administration as a it is a fat-soluble vitamin. Reports of hypersensitivity of ...
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