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However, several regions of the mRNA are usually not translated into protein, including the 5' and 3' UTRs. Although they are called untranslated regions, and do not form the protein-coding region of the gene, uORFs located within the 5' UTR can be translated into peptides. [1] The 5' UTR is upstream from the coding sequence. Within the 5' UTR ...
UTRdb and UTRsite; Content; Description: sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs: Organisms: Eukaryotes: Contact; Laboratory
The 3' UTR of flavivirus - and sometimes even a small part of the 3' end of the coding region - is also called subgenomic flavivirus RNA (sfRNA). [5] It has been shown that sfRNA is implied in many different pathways that comprises both, host defenses and viral infection.
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of translation of a transcript by differing mechanisms in viruses , prokaryotes and eukaryotes .
In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon. The 3′-UTR often contains regulatory regions that post-transcriptionally influence gene expression .
The capsid-coding hairpin region (cHP) actually lies in the ORF of the viral genome and is followed by the 5'CS (conserved sequence), which forms another long-range RNA-RNA interaction with the 3' UTR (3'CS). [5] The cHP aids in the start codon recognition and viral replication.
RNA is similar to DNA, except that RNA contains uracil, instead of thymine, which forms a base pair with adenine. An important region for the activity of gene repression and expression found in RNA is the 3' untranslated region. This is a region on the 3' terminus of RNA that will not be translated to protein but includes many regulatory regions.
The strict regulation of translation in both space and time is in part governed by cis-regulatory elements located in 5′ mRNA transcript leaders (TLs) and 3′ untranslated regions (UTRs). Due to their role in translation initiation, mRNA 5′ transcript leaders (TLs) strongly influence protein expression.