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Nitric oxide supplements contain ingredients that stimulate nitric oxide production in the body. While nitric oxide can be obtained from diet alone, nitric oxide supplements may offer additional ...
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Biological functions of nitric oxide are roles that nitric oxide plays within biology. Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of N O . In mammals including humans, nitric oxide is a signaling molecule involved in several physiological and pathological processes. [ 1 ]
Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure. [8] Sildenafil acts by blocking phosphodiesterase 5 (PDE 5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8]
Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α 1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions, however, nitric oxide attenuates norepinephrine vasoconstriction.
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