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In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP). The cross-linked form of PVP is used as a disintegrant (see also excipients ) in pharmaceutical tablets. [ 1 ]
N-Vinylpyrrolidone (NVP) is an organic compound consisting of a 5-membered lactam ring linked to a (2 carbon) vinyl group. It is a colorless liquid although commercial samples can appear yellowish. It is produced industrially by vinylation of 2-pyrrolidone, i.e. the base-catalyzed reaction with acetylene. [2]
N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
2-Pyrrolidone itself is used in inkjet cartridges. [5] A variety of pharmaceutical drugs are 2-pyrrolidone derivatives, including cotinine, doxapram, povidone, and ethosuximide, and the racetams. The chemical is an intermediate in the production of the polyvinylpyrrolidone precursor vinylpyrrolidone. [3]
The addition product of methanol to 2-vinylpyridine, 2-(2-methoxyethyl)pyridine is a veterinary anthelmintic. [1] Treating 2-vinylpyridine with 4-pyridinecarbonitrile and hydrogen chloride gives 1-[2-(2-pyridyl)ethyl]-4-cyanopyridinium chloride, which then can be used to prepare dimethylaminopyridine (DMAP), a widely used base catalyst.
Racetams are 2-pyrrolidone derivatives and may sometimes be referred to simply as pyrrolidones (2-oxopyrrolidines). [1] Many, but not all, specifically have a 2-oxo-1-pyrrolidine acetamide nucleus, which is the chemical structure of piracetam. Racetams are cyclic derivatives of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). [2]
This electrophile attacks the C-2 carbon of an unoxidized molecule of pyrrole to give a dimeric cation [(C 4 H 4 NH) 2] ++. The process repeats itself many times. Conductive forms of PPy are prepared by oxidation ("p-doping") of the polymer: (C 4 H 2 NH) n + 0.2 X → [(C 4 H 2 NH) n X 0.2] The polymerization and p-doping can also be effected ...