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Metformin (Glucophage) is considered a better drug for these patients. Sulfonylureas should be used with caution or generally avoided in patients with hepatic and renal impairment, patients with porphyria, patients who are breastfeeding, patients with ketoacidosis, and elderly patients. [1] [2]
Metformin may result in a reduction of OHSS but could come with a greater frequency of side effects. [54] There was uncertainty as to metformin's impact on miscarriage. [54] The evidence does not support general use during pregnancy for improving maternal and infant outcomes in obese women. [55]
Like insulin, sulfonylureas can induce weight gain, mainly as a result of their effect to increase insulin levels and thus use of glucose and other metabolic fuels. Other side-effects are: gastrointestinal upset, headache and hypersensitivity reactions. The safety of sulfonylurea therapy in pregnancy is unestablished.
Among the 199 participants, 154 took a daily dose of up to 2,500mg of metformin for six months — the average metformin dose was 2,230mg daily. The remaining 45 participants weren’t treated ...
Sulfonylureas are among the oldest diabetes medications in use, discovered in 1946 and introduced clinically in 1956. They work by stimulating beta cells in the pancreas, promoting insulin production.
Metformin is an example of a class of medicine called biguanides. [34] The medication works by reducing the new creation of glucose from the liver and by reducing absorption of sugar from food. [34] In addition, the medication also works to help increase the effects of insulin on muscle cells, which take in glucose. [35]