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Carcinogenic parasites are parasitic organisms that depend on other organisms (called hosts) for their survival, and cause cancer in such hosts.Three species of flukes are medically-proven carcinogenic parasites, namely the urinary blood fluke (Schistosoma haematobium), the Southeast Asian liver fluke (Opisthorchis viverrini) and the Chinese liver fluke (Clonorchis sinensis).
Clonorchis sinensis under a light microscope: Notice the uterus; this species is monoecious. An adult C. sinensis is a flattened (dorsoventrally) and leaf-shaped fluke. The body is slightly elongated and slender, measuring 15–20 mm in length and 3–4 mm in width. [10]
From the Greek opisthen (behind) and orchis (testicle), Opisthorchis is a genus of trematode flatworms whose testes are located in the posterior end of the body. Sebastiano Rivolta is generally credited with discovering the first opisthorchid, which he named Distoma felineus, in a cat in Italy in 1884.
Symptoms of opisthorchiasis are indistinguishable from clonorchiasis. [4] About 80% of infected people have no symptoms, though they can have eosinophilia. [1] Asymptomatic infection can occur when there are less than 1000 eggs in one gram of feces. [1] Infection is considered heavy when there are 10,000-30,000 eggs in one gram of feces. [1]
Clonorchis sinensis is a trematode (fluke) which is part of the phylum Platyhelminthes. The parasitic worm is as long as 10 to 25 mm and lives in the bile ducts of the liver. It is a hermaphroditic fluke that requires two intermediate hosts. The eggs of the worms are passed in fecal matter into a body of water and are then ingested by mollusks.
Liver fluke is a collective name of a polyphyletic group of parasitic trematodes under the phylum Platyhelminthes. [1] They are principally parasites of the liver of various mammals, including humans. Capable of moving along the blood circulation, they can occur also in bile ducts, gallbladder, and liver parenchyma. In these organs, they ...
Opisthorchiidae is a family of digenean trematodes. Opisthorchiidae have cosmopolitan distribution. [1]The most medically important species in the family Opisthorchiidae are Clonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus, [1] that are causes of the disease clonorchiasis.
Along with other helminth parasites Clonorchis sinensis and Opisthorchis viverrini, S. haematobium was declared as Group 1 (extensively proven) carcinogens by the WHO International Agency for Research on Cancer (IARC) Working Group on the Evaluation of Carcinogenic Risks to Humans in 2009. [6]