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A colorectal polyp is a polyp (fleshy growth) occurring on the lining of the colon or rectum. [1] Untreated colorectal polyps can develop into colorectal cancer. [2] Colorectal polyps are often classified by their behaviour (i.e. benign vs. malignant) or cause (e.g. as a consequence of inflammatory bowel disease).
The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion of the colorectal adenocarcinoma ( colon cancer ). [ 1 ] [ 2 ] [ 3 ] They often manifest as colorectal polyps .
The polyp to cancer progression sequence is the classical model of colorectal cancer pathogenesis. [57] In this adenoma-carcinoma sequence , [ 58 ] normal epithelial cells progress to dysplastic cells such as adenomas , and then to carcinoma, by a process of progressive genetic mutation. [ 59 ]
One’s biological age, which measures the body’s physiological state, may help predict who is at risk for developing colon polyps, a known risk factor for colorectal cancer.
For instance, if you have a chronic bowel condition, a family history of colon polyps or a family history of colon cancer, you may need your first screening colonoscopy earlier than 45 years old ...
Polyps are growths in the lining of the rectum and colon. Although many polyps are not cancerous in the beginning, they may become cancerous over time. It is challenging for a doctor to predict ...
The figure in this section includes a photo of a freshly resected and lengthwise-opened segment of the colon showing a colon cancer and four polyps. Below the photo, there is a schematic diagram of how a large patch of mutant or epigenetically altered cells may have formed, shown by the large area in yellow in the diagram.
For example, adenomatous polyps in the colon may be pedunculated (lobular head with a long slender stalk) or sessile (broad base). The adenomatous proliferation is characterized by different degrees of cell dysplasia ( atypia or loss of normal differentiation of epithelium) irregular cells with hyperchromatic nuclei, stratified or ...
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