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Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). [ 2 ] [ 8 ] Early on, there are typically no symptoms. [ 2 ] Later, non-painful lymph node swelling, feeling tired, fever , night sweats , or weight loss for no clear reason may occur.
CLL/SLL is the most common adult leukemia in Western countries, accounting for 1.2% of the new cancers diagnosed each year in the United States. It usually occurs in older adults (median age at diagnosis 70) and follows an indolent course over many years. [11] About 1-10% of CLL/SLLs develop a Richter's transformation at a rate of 0.5–1% per ...
The key factor that distinguishes low-count CLL/SLL-MLB, high-count CLL/SLL-MLB, and CLL/SLL is the number of circulating monoclonal B cells, as described above. However, the other MLB phenotypes may progress to and/or be mimicked by various monoclonal B-cell lymphocyte malignancies.
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Hematologists base CLL treatment on both the stage and symptoms of the individual person. A large group of people with CLL have low-grade disease, which does not benefit from treatment. Individuals with CLL-related complications or more advanced disease often benefit from treatment. In general, the indications for treatment are:
Lymphoid leukemias are a group of leukemias affecting circulating lymphocytes, a type of white blood cell.The lymphocytic leukemias are closely related to lymphomas of the lymphocytes, to the point that some of them are unitary disease entities that can be called by either name (for example, adult T-cell leukemia/lymphoma).
Hyperleukocytosis is common in chronic myelogenous leukemia and chronic lymphocytic leukemia, but leukostasis rarely occurs. [7] Similarly, the incidence of hyperleukocytosis in people with acute lymphoblastic leukemia is between 10 and 30% but rarely does this progress to symptomatic leukostasis. [7]
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