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After internalization, the receptors dissociate from their ligands when they are exposed to lower pH in endosomes. After dissociation, the receptor folds back on itself to obtain a closed conformation and recycles to the cell surface. [22] The rapid recycling of LDL receptors provides an efficient mechanism for delivery of cholesterol to cells.
In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. [4] Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. [5 ...
4043 16976 Ensembl ENSG00000163956 ENSMUSG00000029103 UniProt P30533 P55302 RefSeq (mRNA) NM_002337 NM_013587 RefSeq (protein) NP_002328 NP_038615 Location (UCSC) Chr 4: 3.5 – 3.53 Mb Chr 5: 35.25 – 35.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha-2-MRAP_N haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein ...
When LDL receptors bind LDL particles in the bloodstream, the clathrin-coated pits are endocytosed into the cell. [citation needed] Vesicles containing LDL receptors bound to LDL are delivered to the endosome. In the presence of low pH, such as that found in the endosome, LDL receptors undergo a conformation change, releasing LDL. LDL is then ...
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene. [ 5 ] [ 6 ] LOX-1 is the main receptor for oxidized LDL on endothelial cells , macrophages , smooth muscle cells , [ 7 ] and other cell types. [ 8 ]
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. [5] [6] [7] ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of ...
Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene. [5] The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTB) domain. The PTB domain has been found to interact with the cytoplasmic tail of the LDL receptor.
53353 94217 Ensembl ENSG00000168702 ENSMUSG00000049252 UniProt Q9NZR2 Q9JI18 RefSeq (mRNA) NM_018557 NM_053011 RefSeq (protein) NP_061027 n/a Location (UCSC) Chr 2: 140.23 – 142.13 Mb Chr 2: 40.49 – 42.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene. Function LRP1B ...