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Diltiazem, sold under the brand name Cardizem among others, is a nondihydropyridine calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias. [9] It may also be used in hyperthyroidism if beta blockers cannot be used. [ 9 ]
Structural formula of diltiazem. Benzothiazepine calcium channel blockers belong to the benzothiazepine class of compounds and are an intermediate class between phenylalkylamine and dihydropyridines in their selectivity for vascular calcium channels. By having both cardiac depressant and vasodilator actions, benzothiazepines are able to reduce ...
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Most people who have taken too much of a calcium channel blocker, especially diltiazem, get slow heart rate and low blood pressure (vasodilatory shock). [1] This can progress to the heart stopping altogether. [2] CCBs of the dihydropyridine group, as well as flunarizine, predominantly cause reflex tachycardia as a reaction to the low blood ...
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For drugs that are moderate CYP3A inhibitors, such as diltiazem, verapamil, and erythromycin, the dose of ranolazine should be reduced. [10] Drugs that are metabolized by CYP2D6, such as tricyclic antidepressants, may need to be given at reduced doses when administered with ranolazine. [10]
1,3-thiazepine 1,4-thiazepine Diltiazem. 1,4-thiazepine is the seven membered ring in the middle. Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. [1] Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine. [1]
"And in the End..." is the series finale of the American medical drama television series ER. The two-hour episode, which serves as the 22nd episode of the fifteenth season and the 331st episode overall, was written by John Wells and directed by Rod Holcomb and aired on NBC on April 2, 2009.
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