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Erythromelalgia or Mitchell's disease (after Silas Weir Mitchell) is a rare vascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed.
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Erythromelalgia is a rare clinical disorder causing redness, burning sensation and intense pain in limbs. [12] It is more common to be found in lower limbs than upper limbs. [ 12 ] Erythromelalgia initiated from dysfunction of peripheral nerves that thickens the blood vessel walls, resulting in hyperaemic flow in limbs.
Mitchell's disease (erythromelalgia) is named after him. He also coined the term phantom limb during his study of an amputee. [6] Mitchell discovered and treated causalgia (today known as CRPS/RSD), a condition most often encountered by hand surgeons. Mitchell is considered the father of medical neurology and a pioneer of "evidence-based" or ...
Chilblains (also clinically presenting as the opposite of Raynaud's, with hot and itchy extremities; however, it affects smaller areas than erythromelalgia, for instance, the tip of a toe rather than the whole foot) Raynaud syndrome can precede these other diseases by many years, making it the first presenting symptom.
PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel Na V 1.7 encoded by the gene SCN9A .
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Livedo reticularis is a common skin finding consisting of a mottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin. [1] The discoloration is caused by reduction in blood flow through the arterioles that supply the cutaneous capillaries, resulting in deoxygenated blood showing as blue discoloration ().