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Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. [5] It is not useful in cerebral palsy. [5] It is taken by mouth. [5] Common side effects include headache, feeling tired, dizziness, and dry mouth. [5]
Kidney disease results from kidney damage and subsequent decline in kidney function, says Dr. Pooja Budhiraja, a nephrologist and hypertension specialist at Mayo Clinic. She explains that there ...
Proper kidney function depends upon adequate blood flow to the kidney. Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. Under normal circumstances, prostaglandin E2 (PGE 2) produced by the kidney is necessary to support adequate blood flow to the kidney.
There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium).
Upon presentation of decreased renal function, it is recommended to perform a history and physical examination, as well as performing a renal ultrasound and a urinalysis. [ citation needed ] The most relevant items in the history are medications , edema , nocturia , gross hematuria , family history of kidney disease, diabetes and polyuria .
The clinical effectiveness of methocarbamol compared to other muscle relaxants is not well-known. [12] One trial of methocarbamol versus cyclobenzaprine, a well-studied muscle relaxant, in those with localized muscle spasm found there were no significant differences in their effects on improved muscle spasm, limitation of motion, or limitation of daily activities.
A simple means of estimating renal function is to measure pH, blood urea nitrogen, creatinine, and basic electrolytes (including sodium, potassium, chloride, and bicarbonate). As the kidney is the most important organ in controlling these values, any derangement in these values could suggest renal impairment.
Eperisone should be administered with care in patients with a history of hypersensitivity to any medication, or with disorders of liver function (it may aggravate hepatic dysfunction). Weakness, light-headedness, sleepiness or other symptoms may occur. In the event of such symptoms, the dosage should be reduced or treatment discontinued.
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related to: cyclobenzaprine and kidney function"The lowest prices on generic prescriptions." - The New York Times