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The replication crisis [a] is an ongoing methodological crisis in which the results of many scientific studies are difficult or impossible to reproduce. Because the reproducibility of empirical results is an essential part of the scientific method , [ 2 ] such failures undermine the credibility of theories building on them and potentially call ...
It has resulted in two major initiatives focusing on the fields of psychology [1] and cancer biology. [2] The project has brought attention to the replication crisis, and has contributed to shifts in scientific culture and publishing practices to address it. [3]
Replication of DNA always begins at an origin of replication. In yeast, the origins contain autonomously replicating sequences (ARS), distributed throughout the chromosome about 30 kb from each other. They allow replication of DNA wherever they are placed. Each one is 100-200 bp long, and the A element is one of the most conserved stretches.
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
The growth of metascience and the recognition of a scientific replication crisis have bolstered the paper's credibility, and led to calls for methodological reforms in scientific research. [8] [9] In commentaries and technical responses, statisticians Goodman and Greenland identified several weaknesses in Ioannidis' model.
Replication (scientific method), one of the main principles of the scientific method, a.k.a. reproducibility Replication (statistics), the repetition of a test or complete experiment; Replication crisis; Self-replication, the process in which an entity (a cell, virus, program, etc.) makes a copy of itself
The authors continued to sample cells as replication continued. DNA from cells after two replications had been completed was found to consist of equal amounts of DNA with two different densities, one corresponding to the intermediate density of DNA of cells grown for only one division in 14 N medium, the other corresponding to DNA from cells ...
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. [1] Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full ...