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Lisinopril/amlodipine, sold under the brand name Lisonorm among others, is a medication used to treat high blood pressure. [1] It is a combination of lisinopril an ACE inhibitor with amlodipine a calcium channel blocker. [1] It may be used when blood pressure is not well controlled with each of the two agents alone. [4] It is taken by mouth. [1]
Lisinopril is taken orally (swallowed by mouth). [7] Full effect may take up to four weeks to occur. [7] Common side effects include headache, dizziness, feeling tired, cough, nausea, and rash. [7] Serious side effects may include low blood pressure, liver problems, hyperkalemia (high blood potassium), and angioedema. [7]
Side effects occurring less than 1% of the time include: blood disorders, impotence, depression, peripheral neuropathy, insomnia, tachycardia, gingival enlargement, hepatitis, and jaundice. [7] [32] [33] Amlodipine-associated gingival overgrowth is a relatively common side effect with exposure to amlodipine. [34]
This may occur with the class's better known side effect of dry cough (due to decreased breakdown of bradykinin), though there is no clear relationship between the two side effects. The first dose phenomenon in ACEi is reduced and made safer by avoiding diuretics for 24 hours prior to first dose, taking first dose at night (so avoiding falls ...
The largest study, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) in 2002, concluded that chlorthalidone (a thiazide-like diuretic) was as effective as lisinopril (an ACEi) or amlodipine (a calcium channel blocker). [17] (ALLHAT showed that doxazosin, an alpha-adrenergic receptor blocker, had a higher ...
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Reduced GFR is especially a problem if the patient is concomitantly taking an NSAID and a diuretic. [21] When the three drugs are taken together, the risk of developing renal failure is significantly increased. [22] High blood potassium is another possible complication of treatment with an ACE inhibitor due to its effect on aldosterone ...
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