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Afterhyperpolarization, or AHP, is the hyperpolarizing phase of a neuron's action potential where the cell's membrane potential falls below the normal resting potential. This is also commonly referred to as an action potential's undershoot phase .
Diagram of membrane potential changes during an action potential. Hyperpolarization is a change in a cell's membrane potential that makes it more negative. Cells typically have a negative resting potential, with neuronal action potentials depolarizing the membrane.
Slow afterhyperpolarisation (sAHP) refers to prolonged periods of hyperpolarisation in a neuron or cardiomyocyte following an action potential or other depolarising event. In neurons, trains of action potentials may be required to induce sAHPs; this is unlike fast AHPs that require no more than a single action potential.
The undershoot, or afterhyperpolarization, phase is the period during which the membrane potential temporarily becomes more negatively charged than when at rest (hyperpolarized). Finally, the time during which a subsequent action potential is impossible or difficult to fire is called the refractory period , which may overlap with the other phases.
Sodium channels are highly selective for the transport of ions across cell membranes. The high selectivity with respect to the sodium ion is achieved in many different ways.
Spin exchange optical pumping (SEOP) [3] is one of several hyperpolarization techniques discussed on this page. This technique specializes in creating hyperpolarized (HP) noble gases, such as 3 He, 129 Xe, and quadrupolar 131 Xe, 83 Kr, and 21 Ne. [4] Noble gases are required because SEOP is performed in the gas phase, they are chemically inert, non-reactive, chemically stable with respect to ...
Early afterdepolarizations (EADs) occur with abnormal depolarization during phase 2 or phase 3, and are caused by an increase in the frequency of abortive action potentials before normal repolarization is completed. [1]
Their activation limits the firing frequency of action potentials and is important for regulating afterhyperpolarization in the neurons of the central nervous system as well as many other types of electrically excitable cells. This is accomplished through the hyperpolarizing leak of positively charged potassium ions along their concentration ...