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Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be compliant with their anticonvulsant drug regimen. Medications that lower seizure threshold include the antidepressant and nicotinic antagonist bupropion, the atypical opioid analgesics tramadol and ...
Both newer and older drugs are generally equally effective in new onset epilepsy. [42] The newer drugs tend to have fewer side effects. [42] For newly diagnosed partial or mixed seizures, there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. [42]
Pentylenetetrazol has been used experimentally to study seizure phenomena and to identify pharmaceuticals that may control seizure susceptibility. For instance, researchers can induce status epilepticus in animal models. Pentylenetetrazol is also a prototypical anxiogenic drug and has been extensively used in animal models of anxiety.
Antipsychotics are not recommended for benzodiazepine withdrawal (or other CNS depressant withdrawal states) especially clozapine, olanzapine or low potency phenothiazines, e.g., chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects; if used extreme caution is required. [148]
The term seizure threshold is used to indicate the amount of stimulus necessary to bring about a seizure; this threshold is lowered in epilepsy. [97] In epileptic seizures a group of neurons begin firing in an abnormal, excessive, [26] and synchronized manner. [2] This results in a wave of depolarization known as a paroxysmal depolarizing shift ...
A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures". [1] Repeated stimulation "lowers the threshold" for more seizures to occur. [4] The brains of experimental animals are repeatedly stimulated, usually with electricity, to induce the seizures. [1]
Antidepressants can include SSRIs (which increase serotonin levels in the brain), SNRIs (which increase serotonin and norepinephrine), and atypical antidepressants (Wellbutrin, for example), along ...
Heavy drinking in particular has been shown to possibly have some effect on seizures in epileptics. But studies have not found light drinking to increase the likelihood of having a seizure at all. [citation needed] EEGs taken of patients immediately following light alcohol consumption have not revealed any increase in seizure activity. [16]
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