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This adjustability is important for their application in drug delivery system in which the functional parameters need to be precisely controlled. [8] Preliminary studies indicate that antibiotics and anticancer drugs may be encapsulated in electrospun nanofibers by adding the drug into the polymer solution prior to electrospinning.
One of the issues faced by drug delivery is the solubility of the drug in the body; around 40% of newly detected chemicals found in drug discovery are poorly soluble in water. [28] This low solubility affects the bioavailability of the drug, meaning the rate at which the drug reaches the circulatory system and thus the target site.
Nanocarriers are useful in the drug delivery process because they can deliver drugs to site-specific targets, allowing drugs to be delivered in certain organs or cells but not in others. Site-specificity is a major therapeutic benefit as it prevents drugs from being delivered to the wrong places.
The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug ...
[1] [2] Once synthesized, the capsules can enclose drugs, [6] quantum dots, [1] and other nanoparticles, to list a few examples. Further fine-tuning of the chemical and topological properties of these polymer capsules could prove an effective route to create drug-delivery systems. [1] [6]
Biological objects of different complexity and synthetic objects carrying specific functions can be incorporated into such nanostructured polymer systems while keeping their specific functions vital. Biosensors, tissue engineering, drug delivery, or enzymatic catalysis is just a few of the possible examples.
Nanofabrics research is an interdisciplinary effort involving bioengineering, [5] molecular chemistry, physics, electrical engineering, computer science, and systems engineering. [3] Applications of nanofabrics have the potential to revolutionize textile manufacturing [6] and areas of medicine such as drug delivery and tissue engineering. [7]
Interestingly, electrospinning allows to fabricate nanofibers with advanced architecture [74] that can be used to promote the delivery of multiple drugs at the same time and with different kinetics. [ 75 ] [ 76 ]