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Primary pigmented nodular adrenocortical disease (PPNAD) was first coined in 1984 by Carney et al. It often occurs in association with Carney complex (CNC). CNC is a rare syndrome that involves the formation of abnormal tumours that cause endocrine hyperactivity.
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
The most typical features of microscopic polyangiitis are renal manifestations and general symptoms; lung involvement is also frequently observed. [15] Immune complex small vessel vasculitis (SVV) is a vasculitis that primarily affects small vessels and has moderate to significant immunoglobulin and complement component deposits on the vessel ...
The cause is complex and multifaceted. Only a small proportion of patients have CD30+ cells in normal lymphoid tissue. These are the cells that are thought to be the precursors of systemic anaplastic large cell lymphoma.
The second step is immune complex deposition, during which the complexes leave the plasma and are deposited into tissues. Finally, the third step is the inflammatory reaction, during which the classical pathway is activated and macrophages and neutrophils are recruited to the affected tissues. Such reactions may progress to immune complex diseases.
Symptoms Definition/Explanation Lactic Acidosis High levels of lactate in the blood; can cause nausea, vomiting, breathing problems, abnormal heartbeats *In less severe cases, signs of lactic acidosis can include ataxia and episodes may only occur when ill, under stress, or after consuming high amounts of carbohydrates. Hyperammonemia
Common signs and symptoms that develop during chronic inflammation are: [12] Body pain, arthralgia, myalgia; Chronic fatigue and insomnia; Depression, anxiety and mood disorders; Gastrointestinal complications such as constipation, diarrhea, and acid reflux; Weight gain or loss; Frequent infections
Cold agglutinin disease can be primary (unknown cause) or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers. Treatment depends on many factors including the severity of the condition, the signs and symptoms present in each person, and the underlying cause. [3] [4]