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  2. 4-Cyano-3-(trifluoromethyl)aniline - Wikipedia

    en.wikipedia.org/wiki/4-Cyano-3-(trifluoromethyl...

    4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide .

  3. Letts nitrile synthesis - Wikipedia

    en.wikipedia.org/wiki/Letts_nitrile_synthesis

    Benzonitrile is a precursor in the synthesis of Fadrozole, an aromatase inhibitor used in the treatment of breast cancer. [11] 4-(trifluoromethyl)benzonitrile, produced by the Nickel catalyzed cyanation of 4-chlorobenzotrifluoride is a precursor for the antidepressant Fluvoxamine. [12] Restrosynthesis of Fluvoxamine

  4. RU-58841 - Wikipedia

    en.wikipedia.org/wiki/RU-58841

    RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was initially developed in the 1980s by Roussel Uclaf, the French pharmaceutical company from which it received its name.

  5. Ligandrol - Wikipedia

    en.wikipedia.org/wiki/Ligandrol

    LGD-4033 is a nonsteroidal SARM with a pyrrolidinyl-benzonitrile core structure and is also referred to as a quinoline or quinolinone SARM. [3] [12] LG121071 (LGD-121071), a tricyclic quinoline, was the predecessor compound of LGD-4033. [10] The chemical structure of LGD-4033 had not been disclosed as late as 2013.

  6. RU-58642 - Wikipedia

    en.wikipedia.org/wiki/RU-58642

    RU-58642 is a nonsteroidal antiandrogen (NSAA) derived from nilutamide with very high affinity and selectivity for the androgen receptor (AR), which made it among the most potent and efficacious antiandrogens known at the time of its discovery. [1]

  7. Trifluoromethylation - Wikipedia

    en.wikipedia.org/wiki/Trifluoromethylation

    S-(trifluoromethyl)dibenzothiophenium tetrafluoroborate is a commercially available and known trifluoromethylation reagent based on the same principle first documented in 1990. [ 64 ] [ 65 ] In this type of compound sulfur has been replaced by oxygen , selenium and tellurium .

  8. Electrophilic aromatic directing groups - Wikipedia

    en.wikipedia.org/wiki/Electrophilic_aromatic...

    Substituents add ortho to the amine in diethyl-(meta-trifluoromethyl)aniline and ortho to the fluoride in para-fluorobenzaldehyde; When multiple substituents are comparably activating, steric hindrance dominates regioselectivity. Substituents add ortho to the methyl group in para-(tert-butyl)toluene

  9. Cyanonilutamide - Wikipedia

    en.wikipedia.org/wiki/Cyanonilutamide

    This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.