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Metformin can also impair the absorption of calcium and vitamin B12 from your gut, Dr. Gupta adds, “so it is important to take additional vitamin B12 supplementation and maintain adequate ...
Alternatively, if you usually skip lunch or eat light dinners, taking metformin in the morning after breakfast could work best. Stomach and bowel issues can be metformin side effects, especially ...
Metformin can also cause a vitamin B12 deficiency, which may be linked with anemia. Stopping the medication or starting vitamin B12 supplementation appears to reverse this. Seek medical advice if ...
Left untreated, vitamin B12 deficiencies can lead to serious health problems including neurological problems and anemia. [88] Although more research is needed to understand the mechanisms of this association, it is suggested that people who take metformin monitor their vitamin B12 levels and if low, begin supplementation. [87]
Reduced serum levels of vitamin B 12 occur in up to 30% of people taking long-term anti-diabetic metformin. [ 102 ] [ 103 ] Deficiency does not develop if dietary intake of vitamin B 12 is adequate or prophylactic B 12 supplementation is given.
Vitamin B 12 deficiency can be determined, but not always. [14] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [150] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
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