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The disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. Most of the Fugates lived long and healthy lives. The "bluest" of the blue Fugates, Luna Stacy, had 13 children and lived to age 84. [6]
They are known as the "Blue Fugates". [30] Martin Fugate and Elizabeth Smith, who had married and settled near Hazard, Kentucky , around 1800, were both carriers of the recessive methemoglobinemia (met-H) gene, as was a nearby clan with whom the Fugates descendants intermarried.
The name cyanosis literally means the blue disease or the blue condition. It is derived from the color cyan, which comes from cyanós (κυανός), the Greek word for blue. [12] It is postulated by Dr. Christen Lundsgaard that cyanosis was first described in 1749 by Jean-Baptiste de Sénac, a French physician who served King Louis XV. [13]
By 2012, Karason lost his home while battling a heart condition and prostate cancer. He later moved to a homeless shelter in Bellingham, Washington. [6] In 2013, Karason died after a heart attack led to pneumonia and a severe stroke. [7] He was a heavy smoker and underwent a triple bypass surgery in 2008. He was estranged from his wife at the ...
Unless acrocyanosis results from another condition (e.g. malignancy, antiphospholipid syndrome, atherosclerosis, acute ischemic limb, bacterial endocarditis), there is no associated increased risk of disease or death, and there are no known complications. Aside from the discoloration, there are no other symptoms: no pain, and no loss of function.
The most dramatic symptom of argyria is that the skin turns blue or blue-gray. It may take the form of generalized argyria or local argyria. Generalized argyria affects large areas over much of the visible surface of the body. Local argyria shows in limited regions of the body, such as patches of skin, parts of the mucous membrane or the ...
Blue baby syndrome can refer to conditions that cause cyanosis, or blueness of the skin, in babies as a result of low oxygen levels in the blood. This term has traditionally been applied to cyanosis as a result of:. [1] Cyanotic heart disease, which is a category of congenital heart defect that results in low levels of oxygen in the blood. [2]
Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. [5] In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease in diabetics. [6] There have also been reported cases of Frank's sign being a predictor of cerebral ...
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