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This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. It is used as part of a combination regimen. Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events.
The FDA granted the approval of Inmazeb to Regeneron Pharmaceuticals with an indication for the treatment of infection caused by Zaire ebolavirus in October 2020. [2] [6] The drug has also received orphan drug designation from the European Medicines Agency. [23]
The first FDA-approved therapeutic monoclonal antibody was a murine IgG2a CD3 specific transplant rejection drug, OKT3 (also called muromonab), in 1986. This drug found use in solid organ transplant recipients who became steroid resistant. [39] Hundreds of therapies are undergoing clinical trials. Most are concerned with immunological and ...
Dutasteride was patented in 1993 by GlaxoSmithKline and was approved for medical use in 2001. [ 12 ] [ 8 ] In the United States and elsewhere, it is available as a generic medication . [ 5 ] In 2018, it was the 291st-most commonly prescribed medication in the US with more than 1 million prescriptions.
The U.S. Food and Drug Administration on Thursday granted accelerated approval to Amgen's tarlatamab, a targeted immunotherapy for adults in the advanced stages of hard-to-treat small cell lung ...
It was approved for medical use by the US Food and Drug Administration (FDA) in October 2007, [27] [11] the European Union in November 2007, [5] [28] the Medicines and Healthcare products Regulatory Agency (MHRA) in January 2021, [2] and the Therapeutic Goods Administration (TGA) in January 2008. [14]
Geroscience has a long way to go, but there are four FDA-approved drugs that have shown promise to “target the process of aging,” Barzilai says. While not approved as anti-aging treatments ...