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N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [ 1 ] [ 2 ] [ 3 ] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen .
[53] [5] [52] Its metabolism is described as extremely rapid and its elimination half-life and duration as very short. [5] [6] [3] [4] In addition, its duration is described as shorter than that of dimethyltryptamine (DMT). [2] Brain tryptamine levels are increased up to 300-fold by MAOIs in animals. [52]
6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [1] [2] It is the 6-methoxy derivative of the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT. [3]
Psilocin, also known as 4-hydroxy-N,N-dimethyltryptamine (4-OH-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms [7] together with its phosphorylated counterpart psilocybin. Psilocin is a Schedule I drug under the Convention on Psychotropic Substances. [8]
N-Methyltryptamine (NMT), also known as monomethyltryptamine, is a chemical compound of the tryptamine family and a naturally occurring compound found in the human body and certain plants. It is biosynthesized in humans from tryptamine by certain N -methyltransferase enzymes , such as indolethylamine N -methyltransferase .
Bufotenin, also known as dimethylserotonin or as 5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT), is a tryptamine derivative, more specifically, a dimethyltryptamine (DMT) analogue, related to the neurotransmitter serotonin. It is an alkaloid found in some species of mushrooms, plants and toads, especially the skin.
Dimethyltryptamine-N-oxide (DMT-N-oxide) is a dimethyltryptamine metabolite. [1] References This page was last edited on 15 April 2021, at 12:10 (UTC). Text is ...
This enzyme also metabolizes several endogenous substances, such as N,N-Dimethyltryptamine, hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver. [5] [6] [7] Considerable variation exists in the efficiency and amount of CYP2D6 enzyme produced between individuals.