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  2. Gene regulatory network - Wikipedia

    en.wikipedia.org/wiki/Gene_regulatory_network

    Structure of a gene regulatory network Control process of a gene regulatory network. A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell.

  3. Gene regulatory circuit - Wikipedia

    en.wikipedia.org/wiki/Gene_regulatory_circuit

    Genetic regulatory circuits (also referred to as transcriptional regulatory circuits) is a concept that evolved from the Operon Model discovered by François Jacob and Jacques Monod. [ 1 ] [ 2 ] [ 3 ] They are functional clusters of genes that impact each other's expression through inducible transcription factors and cis-regulatory elements .

  4. Biological network inference - Wikipedia

    en.wikipedia.org/wiki/Biological_network_inference

    A gene regulatory network [20] is a set of molecular regulators that interact with each other and with other substances in the cell. The regulator can be DNA, RNA, protein and complexes of these. Gene regulatory networks can be modeled in numerous ways including; Coupled ordinary differential equations, Boolean networks, Continuous networks ...

  5. GeneNetwork - Wikipedia

    en.wikipedia.org/wiki/GeneNetwork

    GeneNetwork is a combined database and open-source bioinformatics data analysis software resource for systems genetics. [1] This resource is used to study gene regulatory networks that link DNA sequence differences to corresponding differences in gene and protein expression and to variation in traits such as health and disease risk.

  6. Cis-regulatory element - Wikipedia

    en.wikipedia.org/wiki/Cis-regulatory_element

    Cis-regulatory elements (CREs) or cis-regulatory modules (CRMs) are regions of non-coding DNA which regulate the transcription of neighboring genes.CREs are vital components of genetic regulatory networks, which in turn control morphogenesis, the development of anatomy, and other aspects of embryonic development, studied in evolutionary developmental biology.

  7. Biological network - Wikipedia

    en.wikipedia.org/wiki/Biological_network

    Signaling networks typically integrate protein–protein interaction networks, gene regulatory networks, and metabolic networks. [19] [20] Single cell sequencing technologies allows the extraction of inter-cellular signaling, an example is NicheNet, which allows to modeling intercellular communication by linking ligands to target genes. [21]

  8. Wagner's gene network model - Wikipedia

    en.wikipedia.org/wiki/Wagner's_gene_network_model

    Wagner's gene network model is a computational model of artificial gene networks, which explicitly modeled the developmental and evolutionary process of genetic regulatory networks. A population with multiple organisms can be created and evolved from generation to generation.

  9. Global coordination level - Wikipedia

    en.wikipedia.org/wiki/Global_coordination_level

    However, inferring the precise pairwise interactions of the gene regulatory network remains challenging due to the large number of functional genes and the inherent stochasticity of these systems. [ 1 ] [ 2 ] Despite these challenges, certain features of the gene regulatory network can still be extracted without fully inferring all the ...