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The Journal of Leukocyte Biology is a monthly peer-reviewed medical journal covering all aspects of immunology. The focus of the journal is on leukocyte physiology and leukocyte behavior within the immune system. Content is available for free after a 12-month embargo. Since 2009, the editor-in-chief has been Luis J. Montaner.
Leukocyte adhesion deficiency is an immunodeficiency caused by the absence of key adhesion surface proteins, including LFA-1. [6] LAD is a genetic defect caused by autosomal recessive genes. [6] The deficiency causes ineffective migration and phagocytosis for impacted leukocytes. [3] Patients with LAD also have poorly functioning neutrophils. [2]
Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, the group of viruses cause respiratory tract infections that can range from mild to lethal.
SARS-CoV-2, the causative agent of COVID-19, was first introduced to humans through zoonosis (transmission of a pathogen to a human from an animal), and a zoonotic spillover event is the origin of SARS-CoV-2 that is considered most plausible by the scientific community.
The Janus kinase (JAK)/signal transducer and the activator of the transcription pathway were at the centre of attention for driving hyperinflammation in COVID-19, i.e., the SARS-CoV-2 infection triggers hyperinflammation through the JAK/STAT pathway, resulting in the recruitment of dendritic cells, macrophages, and natural killer (NK) cells, as ...
Illustration of a coronavirus virion in the respiratory mucosa, showing the positions of the four structural proteins and components of the extracellular environment. [15] The M protein is the most abundant protein in coronavirus virions. [8] [5] [4] It is essential for viral replication. [4]
The class I fusion proteins, a group whose well-characterized examples include the coronavirus spike protein, influenza virus hemagglutinin, and HIV Gp41, are thought to be evolutionarily related. [ 7 ] [ 86 ] The S2 region of the spike protein responsible for membrane fusion is more highly conserved than the S1 region responsible for receptor ...
In SARS-CoV, the causative agent of SARS, the N protein is 422 amino acid residues long [2] and in SARS-CoV-2, the causative agent of COVID-19, it is 419 residues long. [7] [8] Both the N-terminal and C-terminal domains are capable of binding RNA. The C-terminal domain forms a dimer that is likely to be the native functional state. [2]